Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A study of factors influencing access to MDT among patients with stage III to stage IV colorectal cancer: a national multicenter survey.

Frontiers in oncology·2026
Same author

Slow-wave sleep engages brainstem circuitry to prevent stress-induced anxiety.

Neuron·2026
Same author

Transthyretin-mediated regulation of neuropathic pain and anxiety-like behavior in the lateral parabrachial nucleus.

Cell reports·2026
Same author

Study on the Effect of Puerarin-Gadolinium on Rheumatoid Arthritis Rats based on Nontargeted Metabolomics Technology.

ACS pharmacology & translational science·2025
Same author

Preconception computed tomography exposure and risk of stillbirth in a nationwide population based cohort study.

Scientific reports·2025
Same author

Medial preoptic CCKAR mediates anxiety and aggression induced by chronic emotional stress in male mice.

National science review·2025
Same journal

[Association between blood mitochondrial DNA copy number and adverse pregnancy outcomes: a Mendelian randomization analysis].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·2026
Same journal

[Network pharmacology-based investigation of the therapeutic efficacy and molecular targets of Xiangsha Liujunzi Decoction in thyroid cancer].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·2026
Same journal

[En-bloc resection of thyroid cancer using recurrent laryngeal nerve tunnel dissection combined with mesangectomy: a retro-spective analysis of 174 cases].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·2026
Same journal

[Methyltransferase-like protein 7B promotes glycolysis and malignant progression in papillary thyroid carcinoma via the USP28/HIF-1α axis].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·2026
Same journal

[Preparation of all-trans retinoic acid and irinotecan co-loaded liposomes and their <i>in vitro</i> evaluation against anaplastic thyroid cancer].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·2026
Same journal

[Service system models for adolescent mental health in different institutional contexts and their implications for China].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
12:06

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

Published on: August 19, 2025

[Research progress on barrel cortex and its plasticity].

Ming-de Huang1, Yong Han, Yan-qin Yu

  • 1Department of Basic Medical Science, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences
|June 15, 2011
PubMed
Summary
This summary is machine-generated.

Barrel cortex synaptic plasticity, a key neuroscience topic, is studied in rodents due to their sensory cortex topology. This system shows experience-dependent plasticity, with thalamocortical synapses being crucial.

More Related Videos

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

Related Experiment Videos

Last Updated: Jun 1, 2026

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
12:06

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

Published on: August 19, 2025

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
07:14

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains

Published on: January 16, 2026

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Sensory Cortex Research

Context:

  • Rodent primary somatosensory cortex (S1) offers ideal topology for studying synaptic plasticity.
  • Experience-dependent plasticity is prominent in S1 during development and adulthood.
  • Neural circuit alterations drive sensory cortex plasticity.

Purpose:

  • To investigate the mechanisms of synaptic plasticity in the primary somatosensory cortex.
  • To identify key locations of plasticity within the S1 neural circuit.
  • To explore the potential role of inhibitory circuits in S1 plasticity.

Summary:

  • Thalamocortical synapses are identified as a primary site for plasticity in the barrel cortex.
  • Synapses from layer 4 to layer 2/3 and within layer 2/3 are essential for plasticity.
  • The involvement of GABAergic inhibitory circuits in S1 plasticity requires further elucidation.

Impact:

  • Provides foundational knowledge for understanding sensory processing and learning.
  • Highlights the importance of specific synaptic connections in neural circuit function.
  • Identifies areas for future research into inhibitory circuit modulation of plasticity.