Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous retroviral elements in human DNA.

C Leib-Mösch1, R Brack-Werner, T Werner

  • 1III. Medizinische Klinik Mannheim, Universität Heidelberg, Mannheim, Federal Republic of Germany.

Cancer Research
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Brainstem auditory evoked responses in horses with hearing loss and during general anesthesia].

Schweizer Archiv fur Tierheilkunde·2024
Same author

FLT3-directed UniCAR T-cell therapy of acute myeloid leukaemia.

British journal of haematology·2023
Same author

Patient and health provider costs of integrated HIV, diabetes and hypertension ambulatory health services in low-income settings - an empirical socio-economic cohort study in Tanzania and Uganda.

BMC medicine·2021
Same author

Personal and occupational experiences of COVID-19 and their effects on South African health workers' wellbeing.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

[Weaning in a Pandemic Situation - A Position Paper].

Pneumologie (Stuttgart, Germany)·2020
Same author

Predictors of receiving a diagnosis, referral and treatment of depression in people on antiretroviral therapy in South African primary care: a secondary analysis of data from a randomised trial.

Tropical medicine & international health : TM & IH·2020
Same journal

CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.

Cancer research·2026
Same journal

A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

Cancer research·2026
Same journal

Editor's Note: Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib.

Cancer research·2026
Same journal

Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

Cancer research·2026
Same journal

Retraction: Two Functional Epitopes of Pigment Epithelial-Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer.

Cancer research·2026
Same journal

Editor's Note: Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

Cancer research·2026
See all related articles

Endogenous retroviruses are significant parts of vertebrate genomes, inherited like genes. Their potential role in human carcinogenesis and association with neoplasias warrants further investigation.

Area of Science:

  • Genomics
  • Molecular Biology
  • Virology

Background:

  • Endogenous retroviruses (ERVs) are integral components of vertebrate genomes.
  • These elements are inherited as stable Mendelian genes and can be activated by various stimuli.
  • Human genomes contain various retroviral elements related to mammalian retroviruses, resembling proviral structures.

Purpose of the Study:

  • To investigate the presence and characteristics of retroviral elements in the human genome.
  • To explore the potential biological functions and implications of these elements.
  • To assess the possible involvement of endogenous retroviral elements in human carcinogenesis.

Main Methods:

  • Detection and characterization of retroviral elements within the human genome.

Related Experiment Videos

  • Analysis of structural similarities to known mammalian retroviruses.
  • Investigation of expression patterns in human tissues and cell lines.

    • Main Results:

    • Retroviral elements, structurally similar to proviruses, are present in the human genome.
    • Expression of endogenous retroviral elements has been observed in various human tissues and cell lines.
    • A potential association between ERV expression and human neoplasias has been noted.

    Conclusions:

    • Endogenous retroviral elements are a significant, inheritable part of the human genome.
    • While their precise biological functions remain elusive, they may influence genome evolution.
    • These elements possess features suggesting a potential role in the development of human cancers.