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Related Concept Videos

G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...

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Purification of Endogenous Drosophila Transient Receptor Potential Channels
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Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

TRP channel gating physiology.

Andrés Nieto-Posadas1, Andrés Jara-Oseguera, Tamara Rosenbaum

  • 1Departamento de Neurodesarrollo y Fisiología, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México, D.F., 04510, Mexico.

Current Topics in Medicinal Chemistry
|June 16, 2011
PubMed
Summary

Transient Receptor Potential (TRP) channels, including TRPV1, TRPM8, and TRPA1, detect physical and chemical stimuli. This review explores their structural mechanisms for sensing and activation.

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Last Updated: Jun 1, 2026

Purification of Endogenous Drosophila Transient Receptor Potential Channels
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

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Area of Science:

  • Molecular Biology
  • Physiology
  • Biophysics

Background:

  • Transient Receptor Potential (TRP) cation channels are crucial for physiological processes and sensory perception.
  • Thermo TRP channels like TRPV1, TRPM8, and TRPA1 respond to temperature and chemical irritants.

Purpose of the Study:

  • To review key findings on the structural and molecular mechanisms underlying the activation of TRPV1, TRPA1, and TRPM8 channels.
  • To elucidate how these channels detect stimuli and couple sensing domains to channel gating.

Main Methods:

  • Literature review of existing research on TRP channel structure and function.
  • Analysis of characterized agonist binding sites and proposed channel gating models.

Main Results:

  • Significant progress has been made in identifying agonist detection sites on TRP channels.
  • Models describing channel gating behavior have been developed, offering insights into activation mechanisms.

Conclusions:

  • While not fully understood, valuable information exists regarding TRP channel activation mechanisms.
  • Further research into structural-functional relationships is key to fully understanding TRP channel physiology.