Related Experiment Video

Updated: Jun 1, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

HLA-B*51:79 is a novel allele associated with a conserved haplotype

P Perrier1, R Leisenbach, S Tourne

  • 1CHU Brabois, Laboratoire d'histocompatibilité, Bâtiment Hémato-Transfusion, Vandoeuvre-les-Nancy, France. p.perrier@chu-nancy.fr

Tissue Antigens
|June 16, 2011
PubMed

Insights

The B*51:79 allele is linked to a specific set of Human Leukocyte Antigen (HLA) alleles, including HLA-A*68:01, C*01:02, DRB1*14:01, and DQB1*05:03. This conserved haplotype association provides insights into genetic variations within the HLA system.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Population Genetics

Background:

  • The Human Leukocyte Antigen (HLA) complex plays a critical role in immune responses.
  • Specific HLA alleles are associated with various diseases and population genetic structures.
  • Understanding conserved haplotypes is essential for genetic association studies.

Purpose of the Study:

  • To identify and characterize conserved haplotype associations involving the B*51:79 allele.
  • To investigate the linkage disequilibrium patterns within the HLA region.
  • To provide a reference for future genetic studies.

Main Methods:

  • High-resolution HLA typing was performed.
  • Haplotype analysis was conducted to assess linkage disequilibrium.
  • Statistical methods were used to confirm conserved associations.

Main Results:

  • A conserved haplotype association was identified for the B*51:79 allele.
  • This association includes the HLA-A*68:01, C*01:02, DRB1*14:01, and DQB1*05:03 alleles.
  • The observed haplotype demonstrates significant linkage disequilibrium.

Conclusions:

  • The B*51:79 allele is part of a conserved haplotype with specific HLA-A, -C, -DRB1, and -DQB1 alleles.
  • This finding contributes to the understanding of HLA genetic architecture.
  • The identified haplotype can serve as a valuable marker in immunogenetic research.

More Related Videos

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses14:23

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Associated Chromosome Trap for Identifying Long-range DNA Interactions14:49

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genetic Lingo01:11

Genetic Lingo

Overview
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...