Early weight changes after birth and serum high-molecular-weight adiponectin level in preterm infants
Tomohide Yoshida1, Hiraku Nagasaki, Yoshihide Asato
1Department of Pediatrics, Faculty of Medicine, University of Ryukyus, Uehara, Nishihara, Okinawa, Japan.
Insights
Early weight changes in preterm infants impact adiponectin levels, a marker linked to future cardiometabolic disease risk. Nutritional support is key to improving outcomes for infants with extra-uterine growth retardation.
Area of Science:
- Neonatal research
- Endocrinology
- Metabolic disease research
Background:
- Extra-uterine growth retardation (EUGR) in preterm infants is linked to later cardiometabolic disease.
- Adiponectin (ADN) multimeric complexes are key metabolic regulators.
Purpose of the Study:
- To investigate the association between early postnatal weight changes and adiponectin levels in preterm infants.
- To explore the relationship between weight recovery and adiponectin complexes at corrected term.
Main Methods:
- Studied 28 preterm infants (24-33 weeks gestation).
- Measured serum adiponectin (total and high-molecular-weight) and anthropometrics at birth and corrected term.
- Analyzed correlations between weight changes, age to regain birthweight, and adiponectin levels.
Main Results:
- Infants with EUGR showed elevated total and high-molecular-weight adiponectin at corrected term.
- Early weight reduction negatively correlated with H-ADN levels.
- Age to restore birthweight was a significant predictor of total and H-ADN levels.
Conclusions:
- Early infant weight dynamics influence serum adiponectin levels at corrected term.
- Optimizing early nutrition may mitigate EUGR and reduce future cardiometabolic disease risk.
Background:
Extra-uterine growth retardation (EUGR) is associated with an increased risk for cardiometabolic diseases later in life. The aim of the present study was to examine the relationship between early weight change after birth in preterm infants and adiponectin (adn) multimeric complexes.
Methods:
Subjects included 28 preterm infants born between weeks 24 and 33 of gestation. Serum adn multimeric complexes and the anthropometric parameters were measured in preterm infants at birth and at corrected term.
Results:
Bodyweight (BW) decreased during the first week of life, with birthweight restored at approximately 19 days after birth. Nineteen of the subjects had EUGR at corrected term. Total (T)-adn, high-molecular-weight (H)-adn, and the ratio of H-adn to T-adn (H/T-adn) were significantly elevated at corrected term than at birth. Postmenstrual age, birthweight, birth length and lowest BW after birth were positively correlated with H-adn and H/T-adn. Weight reduction after birth was negatively correlated with H-adn. Age to restore birthweight was negatively correlated with T-adn, H-adn and H/T-adn. Stepwise multiple regression analysis indicated age to restore birthweight as the major predictor of T-adn and H-adn.
Discussion:
Early weight changes after birth may alter serum adn level in preterm infants at corrected term. The appropriate nutritional support in the early postnatal period could reduce the prevalence of EUGR and the future risk for cardiometabolic diseases.
