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Related Experiment Video

Updated: Jun 1, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image

A Servais1, V Meas-Yedid, L H Noël

  • 1Department of Nephrology, Assistance publique-Hôpitaux de Paris, Necker-Enfants Malades Hospital, Paris, France. aude.servais@nck.aphp.fr

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|June 16, 2011
PubMed
Summary

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Interstitial fibrosis (IF) is present before kidney transplant and progresses significantly in the first three months. Early intervention post-transplant is crucial for managing IF and preserving kidney function.

Area of Science:

  • Nephrology
  • Transplantation Medicine
  • Medical Imaging Analysis

Background:

  • Screening renal biopsies (RB) are utilized to detect early interstitial fibrosis (IF) post-kidney transplantation.
  • Quantifying IF progression is essential for understanding long-term graft outcomes.

Purpose of the Study:

  • To quantitatively assess interstitial fibrosis (IF) using automated color image analysis on sequential renal biopsies (RB).
  • To evaluate the correlation between IF progression and estimated glomerular filtration rate (eGFR) and identify associated risk factors.

Main Methods:

  • Analysis of sequential RB from 140 renal transplant recipients at Day 0, Month 3, and Month 12.
  • Automated color segmentation imaging was employed to quantify IF.
  • Statistical analysis correlated IF scores and evolution with eGFR and clinical parameters.

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Last Updated: Jun 1, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
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Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

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Main Results:

  • Mean IF scores increased from 19% at baseline to 32% at 12 months post-transplant, with accelerated progression in the first 3 months.
  • IF at Month 3 and Month 12 correlated with eGFR at various time points.
  • IF evolution between baseline and Month 3 was linked to long-term eGFR and associated with male donor gender, acute rejection, and diabetes mellitus.

Conclusions:

  • Significant interstitial fibrosis is present even before kidney transplantation.
  • The initial 3 months post-transplant show the most critical period for IF progression, impacting future kidney function.
  • Early therapeutic interventions targeting IF within the first 3 months are recommended to improve graft survival.