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[Relationship between plasma levels of vasoactive intestinal peptide and feeding intolerance in preterm infants]

Jing Xu1, Run-Zhong Huang, Jian-Wei Huang

  • 1Department of Neonatology, First Affiliated Hospital, Jinan University, Guangzhou 510630, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|June 16, 2011
PubMed

Insights

Plasma levels of vasoactive intestinal peptide (VIP) were lower in preterm infants with feeding intolerance (FI). Lower VIP levels on day 1 predicted longer duration of FI, suggesting VIP may predict FI development.

Area of Science:

  • Neonatal physiology
  • Gastroenterology
  • Endocrinology

Context:

  • Feeding intolerance (FI) is a common complication in preterm infants.
  • Vasoactive intestinal peptide (VIP) plays a role in gastrointestinal function.
  • Understanding factors contributing to FI is crucial for improving neonatal outcomes.

Purpose:

  • To investigate plasma vasoactive intestinal peptide (VIP) levels in preterm infants with feeding intolerance (FI).
  • To determine the relationship between plasma VIP levels and the development and duration of FI.
  • To explore the potential of VIP as a predictive biomarker for FI in neonates.

Summary:

  • Plasma VIP concentrations were measured in 53 preterm infants with FI and compared to 59 controls.
  • Fasting plasma VIP levels were significantly lower in the FI group during the first week of life.
  • Lower initial VIP levels correlated with a longer duration of FI, with levels normalizing by day 14.

Impact:

  • Plasma VIP levels may be implicated in the pathophysiology of feeding intolerance in preterm infants.
  • VIP levels could serve as an early predictive marker for the development and severity of FI.
  • This research may inform strategies for managing and potentially preventing feeding intolerance in vulnerable neonates.
Abstract

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