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Related Experiment Video

Updated: Jun 1, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Recent developments in kidney cancer.

Michael J Leveridge¹, Michael A S Jewett

¹Assistant Professor, Department of Urology, Kingston General Hospital, Queen's University, Kingston, ON;

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada

|June 16, 2011

Summary

Recent advances in renal cell carcinoma (RCC) management include improved diagnosis of small masses with biopsy, active surveillance, and thermal ablation. For metastatic RCC, targeted therapies and partial nephrectomy are now standard, improving patient outcomes.

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Last Updated: Jun 1, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Published on: April 12, 2017

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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Area of Science:

Oncology
Urology

Background:

Renal cell carcinoma (RCC) diagnosis and management have evolved significantly.
Increasing diagnosis of small renal masses necessitates alternative management strategies.
Advances in systemic therapies have transformed metastatic RCC treatment.

Purpose of the Study:

To review recent evidence in renal cell carcinoma (RCC) diagnosis and management.
To highlight shifts in the treatment of small renal masses and metastatic disease.
To provide an overview of current oncologic management strategies for RCC.

Main Methods:

Review of recent clinical trials and evidence in RCC management.
Analysis of data on renal mass biopsy, active surveillance, and thermal ablation.
Evaluation of systemic therapies and surgical approaches for RCC.

Main Results:

Partial nephrectomy is the standard surgical approach for most low-stage renal masses.
Renal mass biopsy, active surveillance, and thermal ablation are increasingly utilized for small renal masses.
Targeted systemic therapies have improved progression-free survival and overall survival in metastatic RCC.

Conclusions:

Current RCC management emphasizes tailored approaches based on tumor stage and patient factors.
Minimally invasive techniques and targeted therapies represent significant progress in RCC care.
Evidence supports partial nephrectomy, active surveillance, and targeted systemic therapies for optimal RCC patient outcomes.