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Related Experiment Video

Updated: Jun 1, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Tauopathies: one disease or many?

Manon Bouchard¹, Oksana Suchowersky

¹Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques

|June 16, 2011

Summary

Tauopathies, characterized by abnormal tau protein buildup, may represent varied forms of a single disease. Overlapping features suggest clinical presentation depends on lesion location and other factors.

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

Area of Science:

Neuroscience
Neuropathology
Genetics

Background:

Tauopathies involve the abnormal accumulation of tau protein in the brain.
Previously considered distinct, certain tauopathies now show shared characteristics.

Purpose of the Study:

To explore the overlapping clinical, pathological, and genetic features of progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar degeneration.
To investigate the hypothesis that these disorders may be different phenotypes of a single disease process.

Main Methods:

Comparative analysis of clinical presentations.
Pathological examination of brain tissue.
Genetic profiling of affected individuals.

Main Results:

Progressive supranuclear palsy, corticobasal degeneration, and tau-positive frontotemporal lobar degeneration exhibit significant overlap in clinical, pathological, and genetic findings.
These shared features challenge the notion of distinct disease entities.

Conclusions:

The findings suggest that progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar degeneration could be manifestations of a single underlying tauopathy.
Clinical variability may arise from the topographical distribution of tau pathology and other unidentified factors.