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Published on: May 2, 2013
Recurrent tubulointerstitial nephritis and uveitis syndrome in a renal transplant recipient
Isioma Onyekpe1, Mohan Shenoy, Helen Denley
1Department of Paediatric Nephrology, Royal Manchester Children’s Hospital, Manchester, UK.
Abstract:
We report for the time a patient with recurrence of tubulointerstitial nephritis and uveitis (TINU) following renal transplantation. Our patient was diagnosed at the age of 8 years and, despite treatment with systemic steroids, developed established renal failure. At the age of 17 years, he underwent a live-related donor renal transplant. Immunosuppression included tacrolimus, mycophenolate mofetil and prednisolone. Having had normal renal function for 3 years after transplantation, he developed uveitis and decline in the graft function. A biopsy of the allograft demonstrated recurrent granulomatous interstitial nephritis. The recurrence of TINU following transplantation suggests a role for circulating autoantibodies in the disease pathology.
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