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Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Published on: February 21, 2018
Synthesis of oligonucleotide-peptide conjugates for biomedical and technological applications
Methods in Molecular Biology (Clifton, N.J.)
|June 16, 2011
Abstract:
Oligonucleotide-peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides carrying peptide sequences at the 3'-end on a single support. The resulting oligonucleotide-peptide conjugates may be used as exogenous effectors for the specific control of gene expression. In the second part of this chapter, detailed postsynthetic conjugation protocols to introduce peptide sequences into oligonucleotide sequences are also presented.
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