Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and crystal structure of a nickel(II) 2'-deoxy-6-thioguanosine nitrate complex.

Acta crystallographica. Section C, Structural chemistry·2025
Same author

Metal Exchange in Thioguanosine Coordination Polymers of Gold (I) and Silver (I).

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Protonolysis and Condensation Reactions of Alkoxido-Substituted Lindqvist {MW<sub>5</sub>} and Keggin {MPW<sub>11</sub>} Polyoxometalates: Comparative Experimental and Modeling Studies.

Inorganic chemistry·2025
Same author

Templating Iron(III) Oxides on DNA Molecules.

Nanomaterials (Basel, Switzerland)·2024
Same author

Post transition metal substituted Keggin-type POMs as thin film chemiresistive sensors for H<sub>2</sub>O and CO<sub>2</sub> detection.

Chemical communications (Cambridge, England)·2024
Same author

Computational analysis and experimental verification of donor-acceptor behaviour of berberine, and its co-oligomers and co-polymers with ethylenedıoxythıophene.

Scientific reports·2023

Related Experiment Video

Updated: Jun 1, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

DNA-modified single crystal and nanoporous silicon.

Andrew Houlton1, Bernard A Connolly, Andrew R Pike

  • 1Chemical Nanoscience Laboratory, School of Chemistry, Newcastle University, Newcastle upon Tyne, UK. andrew.houlton@ncl.ac.uk

Methods in Molecular Biology (Clifton, N.J.)
|June 16, 2011
PubMed
Summary

Researchers describe modifying silicon surfaces with DNA oligonucleotides using automated synthesis. This creates semiconductor surfaces that can capture complementary DNA strands.

More Related Videos

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Related Experiment Videos

Last Updated: Jun 1, 2026

Monitoring Protein Adsorption with Solid-state Nanopores
08:51

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Silicon-based materials are widely used in electronics and nanotechnology.
  • DNA oligonucleotides are crucial for molecular biology and diagnostics.
  • Covalent modification of surfaces enhances stability and functionality.

Purpose of the Study:

  • To develop a method for functionalizing silicon surfaces with DNA oligonucleotides.
  • To create semiconductor surfaces capable of specific DNA strand capture.
  • To enable applications in biosensing and molecular electronics.

Main Methods:

  • Automated solid-phase synthesis was employed for DNA oligonucleotide attachment.
  • Functionalization was performed on various silicon forms: crystalline wafers, nanoporous layers, and nanocrystalline particles.
  • Characterization of the modified surfaces confirmed covalent linkage.

Main Results:

  • Successfully achieved covalent modification of silicon surfaces with DNA oligonucleotides.
  • Demonstrated the ability of functionalized surfaces to capture complementary oligonucleotide strands.
  • The developed procedures are versatile across different silicon nanostructures.

Conclusions:

  • Automated synthesis provides an efficient route for DNA-silicon functionalization.
  • The modified surfaces are suitable for creating DNA-hybridized semiconductor devices.
  • This work advances the integration of semiconductor materials with biological molecules.