Related Experiment Video
Updated: Jun 1, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Lyonin A, a new 9,10-Secograyanotoxin from Lyonia ovalifolia
Zhao-Yuan Wu1, Hai-Zhou Li, Wei-Guang Wang
1The College of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650224, P. R. China.
Abstract:
Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A (1), together with two known compounds, secorhodomollolides A and D (2 and 3, resp.). The structure of 1 was elucidated by combination of 1D- and 2D-NMR, and MS analyses. Compound 1 turned out to be a new, highly O-acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 μM induced a significantly decreased cAMP level in N1E-115 neuroblastoma cells (p<0.001), indicating neuropharmacological potential.
Related Concept Videos
Diphtheria
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Botulism
Bacterial Toxins
Toxidromes: Clinical Features
Tetanus
