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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Feb 22, 2026

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis

Published on: September 26, 2025

The progress made in determining the Mycobacterium tuberculosis structural proteome.

Matthias T Ehebauer¹, Matthias Wilmanns

¹European Molecular Biology Laboratory - Hamburg, c/o DESY, Hamburg, Germany. wilmanns@embl-hamburg.de

|June 16, 2011

Summary

New drug targets are crucial for combating tuberculosis (TB) due to rising antibiotic resistance. Structural biology and proteomics are key to discovering novel TB drugs and understanding protein functions.

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Last Updated: Feb 22, 2026

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis

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Published on: September 26, 2025

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

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Published on: July 11, 2025

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

Area of Science:

Structural biology
Proteomics
Drug discovery

Background:

Mycobacterium tuberculosis causes millions of deaths annually.
Existing antibiotics are losing efficacy against persistent and drug-resistant tuberculosis strains.
New drug targets and therapies are urgently needed.

Purpose of the Study:

To review progress in determining the Mycobacterium tuberculosis structural proteome.
To highlight the impact of structural data on developing new anti-TB drugs.
To discuss the discovery of crucial mycobacterial protein functions.

Main Methods:

Genomic sequencing of M. tuberculosis.
Determination of M. tuberculosis protein structures using structural biology techniques.
Proteomic analysis for identifying drug targets.

Main Results:

Structural data for 8.5% of M. tuberculosis protein-encoding ORFs have been determined.
Structural biology provides atomic resolution insights into protein function and drug interactions.
Proteomics aids in identifying promising drug targets.

Conclusions:

Advancements in structural biology and proteomics are vital for tuberculosis drug discovery.
Understanding M. tuberculosis protein structures facilitates structure-based drug design.
Continued structural proteomic studies are essential for combating TB.