Oxazoline-based antimicrobial oligomers: synthesis by CROP using supercritical CO2
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Updated: Jun 1, 2026

Green Synthesis of Quinoline-Based Ionic Liquid
Published on: September 27, 2024
Vanessa G Correia1, Vasco D B Bonifácio, Vivek P Raje
1REQUIMTE, Faculdade de Ciências e Tecnologia, Departamento de Química, Universidade Nova de Lisboa, Caparica, Portugal.
Abstract:
A method using supercritical CO(2) to obtain biocompatible 2-oxazoline-based oligomers quaternized with different amines is described. The synthesized oligo(2-oxazoline)s display partial carbamic-acid insertion at one end. The syntheses of quaternary oligo(2-bisoxazoline)s and linear oligoethylenimine hydrochlorides are reported. Oligo(2-methyl-2-oxazoline) and oligo(2-bisoxazoline) quaternized with N,N-dimethyldodecylamine are the most efficient biocidal agents showing fast killing rates against Staphylococcus aureus and Escherichia coli. Linear oligoethylenimine hydrochloride shows the lowest MIC values but higher killing times against both bacteria. Based on the antimicrobial activity studies, a cooperative action of carbamic acid with the ammonium end group is proposed.
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