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Updated: Jun 1, 2026

Genetic Manipulation of the Plant Pathogen Ustilago maydis to Study Fungal Biology and Plant Microbe Interactions
Published on: September 30, 2016
Nongenetic reprogramming of a fungal highly reducing polyketide synthase
Ahmed A Yakasai1, Jack Davison, Zahida Wasil
1School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Abstract:
The biosynthesis of the fungal metabolite tenellin from Beauveria bassiana CBS110.25 was investigated in the presence of the epigenetic modifiers 5-azacytidine and suberoyl bis-hydroxamic acid and under conditions where individual genes from the tenellin biosynthetic gene cluster were silenced. Numerous new compounds were synthesized, indicating that the normal predominant biosynthesis of tenellin is just one outcome out of a diverse array of possible products. The structures of the products reveal key clues about the programming selectivities of the tenellin polyketide synthase.
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