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Related Experiment Video

Updated: Jun 1, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

Congenital heart disease infant death rates decrease as gestational age advances from 34 to 40 weeks.

James F Cnota¹, Resmi Gupta, Erik C Michelfelder

¹The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. james.cnota@cchmc.org

The Journal of Pediatrics

|June 17, 2011

Summary

This summary is machine-generated.

Congenital heart disease infant mortality decreases as gestational age increases. Full-term infants (34-40 weeks) show lower death rates, suggesting caution with early elective deliveries.

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Area of Science:

Neonatal Health
Perinatal Mortality
Congenital Heart Disease Epidemiology

Background:

Congenital heart disease (CHD) is a significant cause of infant mortality.
Understanding the impact of gestational age on CHD outcomes is crucial for clinical practice.

Purpose of the Study:

To analyze CHD death rates in infants born between 34 and 40 weeks gestation.
To determine the relationship between gestational age and CHD infant death rates.
To compare CHD death rates across 1- and 2-week gestational age intervals.

Main Methods:

Utilized national linked birth/infant death cohort datasets (2000-2003).
Identified CHD deaths using ICD-10 codes.
Calculated proportional death rates and analyzed the relationship with gestational age.

Main Results:

Analyzed 14.9 million records; 4736 infants (0.04%) born 34-40 weeks had CHD deaths.
Found a significant negative linear relationship (R²=0.97) between CHD death rate and gestational age.
Two-week gestational age intervals showed statistically significant differences in CHD death rates.

Conclusions:

CHD infant death rates decline as gestational age approaches 40 weeks.
Results advise against elective delivery solely for prenatally diagnosed CHD.
Gestational age is a critical factor influencing CHD infant mortality.