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Updated: Jun 1, 2026

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
Published on: June 23, 2023
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro
Tzu Ting Chang1, Shivaji V More, I-Hsuan Lu
1Institute of Chemistry, Academia Sinica, 128 Sec 2, Academia Road, Taipei 115, Taiwan.
Abstract:
Isomalyngamide A (1) and A-1 (2) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A (1), discovery of isomalyngamide A-1 (2) and their synthetic analogs (3-9), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p-FAK, FAK, p-Akt and Akt through β1 integrin-mediated antimetastatic pathway.
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