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Updated: Jun 1, 2026

Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
[Interest of blood markers in predicting radiation-induced toxicity]
J Lacombe1, J Solassol, M Coelho
1Département de cancérologie radiothérapie, CRLC Val-d'Aurelle-Paul-Lamarque, rue Croix-Verte, Montpellier cedex 5, France.
Abstract:
The oncologic outcome and the total dose are highly correlated with the treatment by ionizing radiation. The dose increase (total or per fraction) may provoke late-side effects that are potentially irreversible. The radiation-induced CD8 lymphocyte apoptotic value and the molecular modifications within the lymphocyte are capable of predicting the level of risk of developing late-side effects after curative intent radiotherapy. In this review, we present the different blood assays in this setting and discuss the current possibilities of researches, namely those involving the proteomic process.
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