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Cognitive dysfunction in SLE: development of a screening tool.

T Adhikari¹, A Piatti, M Luggen

¹Division of Immunology, Allergy, and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

|June 17, 2011

Summary

The Montreal Cognitive Assessment (MoCA) shows promise for screening cognitive dysfunction in systemic lupus erythematosus (SLE) patients. This tool offers a faster alternative to traditional methods for detecting cognitive impairment in SLE.

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Area of Science:

Neuroscience
Rheumatology
Clinical Psychology

Background:

Cognitive dysfunction (CD) is a common neuropsychiatric issue in systemic lupus erythematosus (SLE).
Current detection methods, neuropsychological tests (NPT) and Automated Neuropsychological Assessment Metrics (ANAM), are time-consuming and not ideal for screening.
There is a need for efficient tools to identify CD in SLE patients.

Purpose of the Study:

To evaluate the Montreal Cognitive Assessment (MoCA) as a screening tool for CD in SLE patients.
To compare the MoCA's performance against the ANAM, considered the gold standard in this study.
To assess the MoCA's utility for both research and clinical settings.

Main Methods:

Systemic lupus erythematosus (SLE) patients meeting ACR criteria were enrolled.
The Automated Neuropsychological Assessment Metrics (ANAM) was used as the gold standard for cognitive assessment.
The Montreal Cognitive Assessment (MoCA) was administered to assess cognitive function.

Main Results:

Out of 44 patients, 25% (11) were identified with CD by ANAM and 29.5% (13) by MoCA.
MoCA scores showed a significant correlation with ANAM scores (r=0.57, p<0.001).
The MoCA demonstrated a sensitivity of 83% and specificity of 73% using a cutoff score of 26.

Conclusions:

The Montreal Cognitive Assessment (MoCA) is a potentially valuable screening tool for cognitive dysfunction in SLE.
MoCA's efficiency makes it suitable for large-scale epidemiologic studies.
The MoCA can aid in the routine clinical care of SLE patients by facilitating early detection of CD.