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Related Experiment Video

Updated: May 31, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Pulpal progenitors and dentin repair.

Y Harichane¹, A Hirata, S Dimitrova-Nakov

¹INSERM UMR-S, UFR Biomédicales des Saints-Pères, Université Paris Descartes, France.

Advances in Dental Research

|June 17, 2011

Summary

Dental pulp stem cells can form reparative dentin after injury. These findings support stem cell therapies for dental tissue regeneration, offering alternatives to traditional endodontic treatments.

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Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

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Published on: November 24, 2012

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

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Last Updated: May 31, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Area of Science:

Dentistry
Stem Cell Biology
Regenerative Medicine

Background:

Mesenchymal stem cells reside in dental pulp and can form dentin-like tissue.
Their role in reparative dentin formation post-pulp injury remains largely unexplored.
Stem cell therapies show promise for dental tissue repair.

Purpose of the Study:

To investigate the location of dental pulp stem cells activated after injury.
To assess the potential of pulp progenitors for reparative dentin formation.
To explore stem cell-based strategies as alternatives to endodontic treatment.

Main Methods:

Pulp exposure in a preclinical model.
Identification and characterization of proliferative cell zones within the dental pulp.
Evaluation of progenitor cell populations.

Main Results:

Progenitor cells were identified in three distinct zones within the dental pulp post-injury.
Zone III, near the apex, showed mitotic stromal cells, a potential source of progenitor cells.
These findings indicate endogenous stem cells can be activated for repair.

Conclusions:

Dental pulp harbors progenitor cells capable of contributing to reparative dentin formation.
Stem cell-based approaches offer a promising future for regenerative endodontics.
Further research can pave the way for clinical applications of pulp stem cell therapies.