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Updated: May 31, 2026

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
Published on: July 10, 2018
Glutamate NMDA receptors in pathophysiology and pharmacotherapy of selected nervous system diseases
1Department of Pathophysiology, Jagiellonian University Medical College Cracow, Poland. lukaszd@mp.pl
Abstract:
Glutamate is the basic excitatory neurotransmitter acting via N-methyl-D-aspartate receptors (NMDARs). It co-regulates many important physiological functions, including learning, memory, and behaviour. An excess of glutamate, as well as NMDAR over-activity, produce pathological effects. Glutamate-related neurotoxicity is involved in the pathogenesis of many neurological conditions. This article briefly describes the role of the glutamate system in the pathophysiology of brain ischemia, selected neurodegenerative disorders, and schizophrenia. It also reviews the current and potential future status of agents targeting NMDARs in neuropsychopharmacology.
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