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Updated: May 31, 2026
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
Published on: September 13, 2018
WW domain interactions regulate the Hippo tumor suppressor pathway.
1The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Cell Death & Disease
|June 17, 2011
Summary
The Hippo kinase pathway regulates organ growth and cancer. WW domain interactions are key to understanding how this pathway is controlled, offering new therapeutic targets for tumorigenesis.
Area of Science:
- Molecular Biology
- Cell Signaling
- Oncology
Background:
- The Hippo kinase pathway is crucial for organ size control and cancer development in various organisms.
- While core Hippo kinase signaling is understood, its upstream regulation and downstream effects remain less clear.
- WW domains and proline-rich motifs are key interaction modules within the Hippo pathway.
Purpose of the Study:
- To review recent discoveries on WW domain-mediated interactions in Hippo pathway regulation.
- To explore the role of these interactions in tumorigenesis.
- To discuss future research directions in Hippo pathway signaling.
Main Methods:
- Literature review of recent studies on WW domain-mediated interactions.
- Analysis of the role of these interactions in Hippo pathway signaling.
- Synthesis of current knowledge and identification of future research avenues.
Main Results:
- WW domain-mediated interactions offer a versatile mechanism for regulating the Hippo pathway.
- These interactions are increasingly recognized as critical in the development of cancer.
- Specific WW domain interactions provide insights into upstream and downstream regulation of the cascade.
Conclusions:
- WW domain-mediated interactions are vital for understanding Hippo pathway regulation in both normal development and disease.
- Targeting these interactions may offer novel therapeutic strategies for cancer.
- Further research is needed to fully elucidate the complex regulatory network of the Hippo pathway.
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