Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated Antigenic and Nucleic Acid Detection in Single Virions and Extracellular Vesicles with Viral Content.

Advanced healthcare materials·2024
Same author

Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2024
Same author

Engineering a tunable micropattern-array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ.

Journal of extracellular vesicles·2023
Same author

An immunogold single extracellular vesicular RNA and protein (<sup>Au</sup> SERP) biochip to predict responses to immunotherapy in non-small cell lung cancer patients.

Journal of extracellular vesicles·2022
Same author

Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis.

Lab on a chip·2022
Same author

Liposome interaction with macrophages and foam cells for atherosclerosis treatment: effects of size, surface charge and lipid composition.

Nanotechnology·2021

Related Experiment Video

Updated: May 31, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Biomimetic nanostructured materials: potential regulators for osteogenesis?

Michelle Ngiam1, Luong T H Nguyen, Susan Liao

  • 1National University of Singapore (NUS) Graduate School (NGS) for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS).

Annals of the Academy of Medicine, Singapore
|June 17, 2011
PubMed
Summary

Biomimetic nanostructured materials mimic the body's natural environment to guide mesenchymal stem cells (MSCs) toward bone regeneration. These advanced scaffolds promote osteoblastic differentiation for therapeutic bone repair.

More Related Videos

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Related Experiment Videos

Last Updated: May 31, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Nanostructured materials offer unique properties like high surface area and porosity.
  • These materials can mimic the extracellular matrix (ECM) to create artificial microenvironments.
  • Mesenchymal stem cells (MSCs) are crucial for therapeutic treatments due to their differentiation potential.

Purpose of the Study:

  • To review the potential of biomimetic nanostructured materials for bone regeneration.
  • To explore their ability to induce osteoblastic differentiation of MSCs without soluble factors.
  • To highlight the advantages of mimicking native bone nanostructure and ECM components.

Main Methods:

  • Review of literature on nanostructured materials and MSC differentiation.
  • Analysis of biomimetic strategies for scaffold design.
  • Investigation of collagen and hydroxyapatite incorporation in scaffolds.

Main Results:

  • Nanostructured materials effectively mimic native bone ECM.
  • Biomimetic scaffolds promote osteoblastic differentiation of MSCs.
  • Incorporation of collagen and hydroxyapatite enhances osteoinductive properties.

Conclusions:

  • Biomimetic nanostructured materials show significant promise for bone regeneration.
  • These scaffolds can guide MSCs towards osteoblastic lineage, reducing the need for growth factors.
  • Advanced material design is key to successful therapeutic applications in bone repair.