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Metallothionein and brain inflammation.

Yasmina Manso¹, Paul A Adlard, Javier Carrasco

¹Animal Physiology Unit, Department of Cellular Biology, Physiology and Immunology, Faculty of Biosciences, Institute of Neurosciences, Universitat Autonoma Barcelona, Bellaterra, 08193, Barcelona, Spain.

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry

|June 17, 2011

Summary

Metallothioneins (MTs) play a role in neuroinflammation. Injecting human Zn(7)MT-2A into Alzheimer disease mice may reverse behavioral deficits, despite increased amyloid plaques and gliosis.

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Area of Science:

Biochemistry
Neuroscience
Immunology

Background:

Metallothioneins (MTs) are proteins involved in zinc homeostasis and cellular protection.
Neuroinflammation is a key component of neurodegenerative diseases like Alzheimer disease.
Interleukin-6 is a major cytokine implicated in the inflammatory response.

Purpose of the Study:

To review the role of MTs in neuroinflammation.
To investigate the effects of human Zn(7)MT-2A in a mouse model of Alzheimer disease.

Main Methods:

Review of existing literature on MTs and inflammation.
Administration of human Zn(7)MT-2A to Tg2576 Alzheimer disease mice.
Assessment of behavioral deficits, amyloid plaque load, and gliosis.

Main Results:

Preliminary results show reversal of behavioral deficits in treated mice.
Amyloid plaque load and gliosis were enhanced following Zn(7)MT-2A injection.
MTs are implicated in the inflammatory response within the central nervous system.

Conclusions:

Human Zn(7)MT-2A may offer therapeutic potential for Alzheimer disease by improving behavior.
Further research is needed to understand the complex effects of MTs on neuroinflammation and Alzheimer pathology.