Related Experiment Video
Updated: May 31, 2026

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines
Published on: October 11, 2022
Rickets: concerns over the worldwide increase
1Royal Manchester Children's Hospital.
Insights
Rickets, a childhood bone disease, is re-emerging globally due to low vitamin D levels. Increased sun protection and reduced outdoor play contribute to this concerning trend in children.
Area of Science:
- Pediatrics
- Nutritional Science
- Public Health
Background:
- Rickets, characterized by bone softening and deformities, was once thought eradicated in the UK.
- Recent global resurgence of rickets affects children across all socioeconomic strata.
- Primary causes include vitamin D deficiency and inadequate dietary intake.
Purpose of the Study:
- To investigate the re-emergence of rickets in children.
- To identify contributing factors to the rising incidence of childhood rickets.
- To highlight the role of vitamin D deficiency and modern lifestyle in rickets.
Main Methods:
- Review of recent rickets cases and epidemiological data.
- Analysis of public health recommendations regarding sun exposure and vitamin D.
- Examination of lifestyle factors influencing children's outdoor activity and sun exposure.
Main Results:
- Rickets cases are increasing globally, challenging previous notions of eradication.
- Vitamin D deficiency is a primary driver, exacerbated by increased sunscreen use and reduced outdoor play.
- Modern lifestyle, including indoor entertainment, contributes to decreased sun exposure.
Conclusions:
- The re-emergence of rickets underscores the critical importance of vitamin D synthesis through adequate sun exposure.
- Public health strategies must balance sun safety with the essential need for vitamin D production.
- Addressing vitamin D deficiency through supplementation and promoting outdoor activity is crucial for preventing childhood rickets.
Abstract:
Rickets is a childhood disease that causes a softening of the bones, potentially leading to fractures and deformity. Eighty years ago it was thought to have largely been eradicated from the U.K. However a recent increase in cases of rickets, not just in Britain but around the world, has proven this isn't the case. Today the disease affects children from all types of socio-economic backgrounds, not just the poorer ones, and it is primarily caused by low levels of vitamin D and certain foods. In January 2011 the government's chief medical officer Dame Sally Davies recommended all children aged six months to five should be given vitamin D supplements, particularly during winter months when natural sunshine is limited. The irony is that the advice in recent years for children to wear a high factor sunscreen and remain covered up while playing outdoors are partly felt to be behind the reason for its re-emergence. Parents and health professionals alike were shocked when it was revealed that a school girl living on the Isle of Wight developed rickets precisely because of her mother's vigilance at following sun safety rules. NICE, in their latest report (Jan 2011) stated that: "Exposure to the sun has a number of benefits. For example, it increases people's sense of wellbeing, allows them to synthesise vitamin D and provides opportunities for physical activity". A tendency for children to stay indoors and watch TV or play on computer games, rather than play outside when the sun is shining, is arguably also another contributing factor.
Related Concept Videos
Rocky Mountain Spotted Fever
Current Trends in Nursing I
Rheumatic Heart Disease I: Introduction
Post-translational Translocation of Proteins to the RER
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
Restless Leg Syndrome and Night Terrors
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
Rheumatic Heart Disease IV: Nursing Management