Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A safety-centric perspective on innovation and risk in the use of artificial intelligence in genomics.

Trends in genetics : TIG·2026
Same author

BRIDGE pilot study: a bilateral regulatory investigation of data governance and exchange.

NPJ digital medicine·2026
Same author

Machine learning-supported framework for the classification of mpox infection and MVA immunization from multiplexed serology data.

Nature communications·2025
Same author

[Applications, challenges and a trustworthy use of artificial intelligence in public health].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·2025
Same author

Artificial intelligence in public health: promises, challenges, and an agenda for policy makers and public health institutions.

The Lancet. Public health·2025
Same author

The Way Forward to Embrace Artificial Intelligence in Public Health.

American journal of public health·2024

Related Experiment Video

Updated: May 31, 2026

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
11:28

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

Drug delivery in soft tissue engineering.

Katharina Ladewig1

  • 1The University of Melbourne, Department of Chemical and Biomolecular Engineering , Parkville VIC, Australia. kladewig@unimelb.edu.au

Expert Opinion on Drug Delivery
|June 18, 2011
PubMed
Summary

Tissue engineering (TE) faces challenges in clinical translation. While many bioactive molecules and scaffolds are explored, limited FDA-approved therapies exist, necessitating further research for regenerative medicine success.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Tissue defects from disease or trauma pose significant challenges in regenerative medicine.
  • Modern tissue engineering (TE) utilizes biodegradable scaffolds, cells, and biomolecules for repair.
  • Environmental cues, including scaffold-surface biomolecules and sustained release, are crucial for TE.

Purpose of the Study:

  • To review drugs and bioactive molecules relevant to tissue engineering.
  • To survey materials proposed for tissue engineering scaffolds and matrices.
  • To discuss encapsulation, immobilization, and controlled release strategies for bioactive proteins, focusing on soft TE.

Main Methods:

  • Literature review of bioactive molecules and scaffold materials for TE.

More Related Videos

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model
08:43

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Published on: February 7, 2018

Related Experiment Videos

Last Updated: May 31, 2026

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
11:28

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model
08:43

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Published on: February 7, 2018

  • Discussion of encapsulation, immobilization, and controlled release techniques for proteins.
  • Focus on recent advancements in soft tissue engineering applications.

    • Main Results:

    • Minimal clinical success has been achieved with growth factor, morphogen, or adhesion factor modified scaffolds.
    • Only one growth factor delivery system (Regranex Gel) is FDA-approved; few other growth factors are approved for human use.
    • Numerous growth factors are in clinical trials, and many delivery systems use FDA-approved materials.

    Conclusions:

    • Clinical translation of TE scaffolds modified with bioactive molecules remains limited.
    • Further research in hydrogel and support material development is needed for soft TE.
    • Advancements in growth factor development and delivery systems are essential for clinical success in soft tissue engineering.