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Updated: May 31, 2026
08:07
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Ovarian endometriomas and IVF: a retrospective case-control study
Francesca Bongioanni1, Alberto Revelli, Gianluca Gennarelli
1Department of Obstetrical and Gynecological Sciences, University of Torino, Anna Hospital, Torino, Italy.
Reproductive Biology and Endocrinology : RB&E
|June 18, 2011
Summary
Ovarian endometriosis does not negatively impact in vitro fertilization (IVF) success rates. Laparoscopic surgery for endometriomas before IVF does not improve outcomes and may reduce ovarian response.
Area of Science:
- Reproductive Medicine
- Gynecology
- In Vitro Fertilization
Background:
- Ovarian endometriosis is a common gynecological condition.
- Its impact on in vitro fertilization (IVF) outcomes is debated.
- Previous surgical intervention for endometriomas may affect ovarian reserve.
Purpose of the Study:
- To compare IVF outcomes between women with ovarian endometriosis and those with tubal infertility.
- To evaluate the effect of prior laparoscopic surgery for ovarian endometriomas on IVF results.
Main Methods:
- Retrospective case-control study of 428 first-attempt IVF cycles.
- Comparison 1: Ovarian endometriosis (n=254) vs. tubal infertility (n=174).
- Comparison 2: Ovarian surgery for endometriomas before IVF (n=112) vs. non-operated endometriomas (n=142).
Main Results:
- Women with ovarian endometriosis had higher IVF cancellation rates but similar pregnancy, implantation, and delivery rates compared to tubal infertility patients.
- Patients with prior ovarian surgery had shorter periods, lower antral follicle counts, and required higher gonadotropin doses.
- Both surgical and non-surgical endometriosis groups showed similar pregnancy, implantation, and live birth rates.
Conclusions:
- Ovarian endometriosis does not adversely affect IVF outcomes compared to tubal factor infertility.
- Laparoscopic removal of ovarian endometriomas prior to IVF does not improve success rates.
- Ovarian surgery for endometriomas may diminish ovarian responsiveness to gonadotropins.
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