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Updated: May 31, 2026

Pupillometry to Assess Auditory Sensation in Guinea Pigs
Published on: January 6, 2023
A train of electrical pulses applied to the primary auditory cortex evokes a conditioned response in guinea pigs
Yuji Okuda1, Hiroshi Shikata, Wen-Jie Song
1Department of Electronic Engineering, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan.
Abstract:
As a step to develop auditory prosthesis by cortical stimulation, we tested whether a single train of pulses applied to the primary auditory cortex could elicit classically conditioned behavior in guinea pigs. Animals were trained using a tone as the conditioned stimulus and an electrical shock to the right eyelid as the unconditioned stimulus. After conditioning, a train of 11 pulses applied to the left AI induced the conditioned eye-blink response. Cortical stimulation induced no response after extinction. Our results support the feasibility of auditory prosthesis by electrical stimulation of the cortex.
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