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Visualization of Bacterial Resistance using Fluorescent Antibiotic Probes

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Published on: March 2, 2020

The newer fluoroquinolones.

Maureen K Bolon¹

¹Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 900, Chicago, IL 60611, USA. m-bolon@northwestern.edu

The Medical Clinics of North America

|June 18, 2011

Summary

This review covers fluoroquinolone antibiotics, detailing their pharmacology, resistance, and safety. It highlights current trends in resistance among key bacteria like gram-negative organisms and Streptococcus pneumoniae.

Area of Science:

Pharmacology and Microbiology
Infectious Diseases
Drug Resistance

Background:

Fluoroquinolones are widely used antibiotics due to their broad spectrum and perceived safety.
Understanding their properties is crucial for effective clinical application.

Purpose of the Study:

To review the pharmacology and pharmacodynamics of fluoroquinolones.
To examine mechanisms and current epidemiology of fluoroquinolone resistance.
To discuss safety concerns and indications for common fluoroquinolones.

Main Methods:

Literature review of fluoroquinolone pharmacology.
Analysis of resistance mechanisms and epidemiological trends.
Discussion of safety profiles and clinical uses.

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Main Results:

Fluoroquinolone use is common, but resistance is an increasing concern.
Emerging resistance patterns in gram-negative bacteria and Streptococcus pneumoniae are noted.
Key safety issues and indications for ciprofloxacin, levofloxacin, and moxifloxacin are detailed.

Conclusions:

Fluoroquinolone efficacy is challenged by rising resistance.
Awareness of resistance trends and safety concerns is vital for appropriate prescribing.
This review provides a comprehensive overview for clinicians.