Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction01:25

Peptic Ulcer Disease I: Introduction

Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Peptic Ulcer Disease II: Pathophysiology01:24

Peptic Ulcer Disease II: Pathophysiology

Peptic ulcer disease develops when protective mechanisms of the gastrointestinal mucosa are overwhelmed by harmful factors, leading to localized erosions in the stomach or proximal duodenum. The main causes are Helicobacter pylori infection and chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs).Helicobacter pylori–Induced InjuryBacterial Adaptation and Colonization:H. pylori is a spiral, Gram-negative bacterium adapted to the acidic stomach. and transmitted through oral-oral or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paroxysmal slow waves mark ictal networks.

Epilepsia·2026
Same author

Paroxysmal Slow Waves Mark Ictal Networks.

medRxiv : the preprint server for health sciences·2026
Same author

Eating-induced seizure: Diagnostic and electroclinical insights from a case with perisylvian features.

Epileptic disorders : international epilepsy journal with videotape·2025
Same author

Impact of cerebral small vessel disease on cognitive outcomes in early age at onset MCI and dementia: Findings from the DIASPORA study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

West Nile virus neuroinvasive disease: Clinical characteristics and prognostic factors.

Journal of the neurological sciences·2025
Same author

Elucidating the Relationship Between Mycosis Fungoides and Contact Sensitization: A Retrospective Study.

Dermatitis : contact, atopic, occupational, drug·2025
Same journal

Letter to the editor in reply to "Ethics of Rising Trends in Dermatology Publications Using Large-Scale Databases".

Clinics in dermatology·2026
Same journal

Ethics of suggesting image-guided superficial radiation therapy on the pathology report.

Clinics in dermatology·2026
Same journal

Tanorexia: The psychodermatology of compulsive tanning.

Clinics in dermatology·2026
Same journal

Ear manifestations of connective tissue diseases: A dermatologic, histopathologic, and clinicopathologic review.

Clinics in dermatology·2026
Same journal

Discovery of an intravenous drug injection site: A meticulous cutaneous examination provides the forensic dermatologic clue to a diagnosis of homicide.

Clinics in dermatology·2026
Same journal

Sherlock Holmes and the mystery of the deadly diet.

Clinics in dermatology·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Drug-induced pemphigus.

Sarah Brenner1, Ilan Goldberg

  • 1Department of Dermatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizmann Street, Tel-Aviv University, Tel Aviv 64239, Israel. i-f-skin@zahav.net.il

Clinics in Dermatology
|June 18, 2011
PubMed
Summary
This summary is machine-generated.

Drug-induced pemphigus, a challenging autoimmune skin condition, requires careful medication review. Identifying the causative drug and discontinuing it can improve patient outcomes.

More Related Videos

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Related Experiment Videos

Last Updated: May 31, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Pemphigus is an autoimmune bullous disease potentially triggered by genetic and external factors.
  • Medications are a significant cause of pemphigus, necessitating detailed patient history to identify offending agents.
  • Diagnosing drug-induced pemphigus is complex due to multiple drug exposures and potential latency periods.

Purpose of the Study:

  • To highlight the diagnostic challenges in drug-induced pemphigus.
  • To emphasize the importance of identifying culprit medications.
  • To discuss the utility of diagnostic tests and treatment strategies.

Main Methods:

  • Review of existing literature on drug-induced pemphigus.
  • Discussion of diagnostic challenges including polypharmacy and latency.
  • Mention of the interferon-gamma (IFN-gamma) release assay for diagnosis.

Main Results:

  • Drug-induced pemphigus diagnosis is complicated by numerous factors.
  • The in vitro interferon-gamma (IFN-gamma) release from lymphocytes test shows diagnostic value.
  • Discontinuation of the causative drug can lead to clinical improvement.

Conclusions:

  • Thorough patient history is crucial for identifying drug-induced pemphigus.
  • The IFN-gamma release assay may aid in diagnosing drug-induced pemphigus.
  • Withdrawal of the offending medication is a key therapeutic step.