Drug-induced pemphigus
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Updated: May 31, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
1Department of Dermatology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizmann Street, Tel-Aviv University, Tel Aviv 64239, Israel. i-f-skin@zahav.net.il
Abstract:
Pemphigus is an autoimmune bullous disease that may be influenced by genetic and exogenous factors. Drugs are a leading cause of pemphigus. There is a need for a thorough history taking so as to find the culprit medication. The diagnosis of drug-induced pemphigus is challenging. Patients have often been exposed to multiple drugs, and some drugs may have a prolonged latency period between exposure and onset of the disease. The in vitro interferon-gamma (IFN-gamma) release from lymphocytes test has been shown to be of diagnostic value in drug-induced skin reactions. Cessation of the offending drug may alleviate the clinical manifestations and reduce the need for medical treatment.
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