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Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
Published on: September 21, 2015
Povidone iodine: features of critical systemic absorption
K Lakhal1, J Faidherbe, R Choukhi
1Réanimation polyvalente, service d'anesthésie-réanimation A, hôpital Lapeyronie, centre hospitalier universitaire, 375, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5, France. lakhal_karim@yahoo.fr
Annales Francaises D'Anesthesie Et De Reanimation
|June 18, 2011
Summary
Povidone iodine (PI) can cause severe systemic toxicity, including renal failure and hemolysis, even after internal use. Early recognition of iodine toxicity is crucial for prompt treatment with renal replacement therapy.
Area of Science:
- Toxicology
- Nephrology
- Gynecology
Background:
- Povidone iodine (PI) is a widely used antiseptic.
- Internal administration of PI carries a risk of significant iodine absorption.
- Potential for severe adverse events necessitates careful consideration of its use.
Observation:
- A case report details a 41-year-old woman experiencing severe complications after intra-uterine PI injection.
- The patient developed hypotension, anuric renal failure, hemolysis, coagulopathy, and uterine infarction.
- Markedly elevated iodemia levels (6929 μg/dL) were observed, requiring 9 days of renal replacement therapy.
Findings:
- Intra-uterine Povidone iodine administration can lead to life-threatening systemic iodine toxicity.
- The clinical presentation included multi-organ dysfunction, highlighting the systemic effects of excessive iodine absorption.
- Renal replacement therapy was essential for managing the acute kidney injury and facilitating iodine clearance.
Implications:
- Extreme caution is advised when Povidone iodine contacts mucosal surfaces.
- Prompt recognition of iodine toxicity symptoms is critical for timely intervention.
- Understanding the risks of internal PI use is vital for patient safety and clinical practice.
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