Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...

Instinct Theory

Instinct Theory

Instinct theory proposes that innate biological instincts, like animal behavioral patterns, primarily drive human behavior. These instincts are inborn, not learned, and are fundamental to decision-making and action. Just as animals rely on instincts for critical survival functions such as migration, nest building, and defense, humans are also believed to exhibit behaviors rooted in evolutionary needs. For example, the instinct to reproduce motivates sexual behavior, while territorial instincts...

McNemar's Test

McNemar's Test

McNemar's Test is a nonparametric statistical test used to determine if there is a significant difference in proportions between two related groups when the outcome is binary (e.g., yes/no, success/failure). It is beneficial when we have paired data, such as pre-test/post-test designs, where the same subjects are measured under two different conditions. The test is named after the statistician Quinn McNemar, who introduced it in 1947. It is commonly used in situations where subjects are...

Gene Flow

Gene Flow

Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.

Maxwell's Equation Of Electromagnetism

Maxwell's Equation Of Electromagnetism

James Clerk Maxwell (1831–1879) was one of the major contributors to physics in the nineteenth century. Although he died young, he made major contributions to the development of the kinetic theory of gases, to the understanding of color vision, and to understanding the nature of Saturn's rings. He is probably best known for having combined existing knowledge on the laws of electricity and magnetism with his insights into a complete overarching electromagnetic theory, which is represented by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Willis and the cortical neuron.

The Lancet. Neurology·2021

Same author

Reply: The etymology of 'neurology', redux: early use of the term by Jean Riolan the Younger (1610).

Brain : a journal of neurology·2021

Same author

Occasional essay: Multiple sclerosis in the digital age: 'seeing through a glass darkly'.

Journal of neurology, neurosurgery, and psychiatry·2020

Same author

Transcript specific regulation of expression influences susceptibility to multiple sclerosis.

European journal of human genetics : EJHG·2020

Same author

Grey Matter Etymology and the neuron(e).

Brain : a journal of neurology·2019

Same author

From the Archives Muscular atrophy, after measles, in three members of a family. By J.A. Ormerod, M.D. Brain (October) 1884; 7 (part XXVII): 334-342; with The peroneal type of progressive muscular atrophy. By Howard H. Tooth, M.A, M.D., M.R.C.P (H.K Lewis, London). 1886; pages 44: with Critical Digests. Recent observations on progressive muscular atrophy. By H. H. Tooth, M.D. Brain (July) 1887; 10 (part XXXVIII): 243-253; with The peroneal form or leg-type of progressive muscular atrophy. By B. Sachs, M.D. (New York). Professor of Mental and Nervous Diseases in the New York Polyclinic, Brain 1890; 12: 447-459.

Brain : a journal of neurology·2019

Same journal

The significance of electrophysiological recordings from the bed nucleus of the stria terminalis in humans.

Brain : a journal of neurology·2026

Same journal

Fus-depleted oligodendrocytes reduce neuronal damage and Alzheimer's disease progression in the AppNL-G-F mouse.

Brain : a journal of neurology·2026

Same journal

Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026

Same journal

Lower motor neuron disorders: time for a closer look.

Brain : a journal of neurology·2026

Same journal

Reply: Cervical lymph node biomarkers in neurodegeneration.

Brain : a journal of neurology·2026

Same journal

Propionic acid and neurofilament light chain in multiple sclerosis.

Brain : a journal of neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 31, 2026

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

Published on: July 20, 2011

William Ian McDonald: 1933-2006.

Alastair Compston¹

¹Brain Editorial Office, ED Adrian Building, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB20PY, UK. brain@medschl.cam.ac.uk

Brain : a Journal of Neurology

|June 18, 2011

Summary

This summary is machine-generated.

This biography details the distinguished career of neurologist Ian McDonald, highlighting his contributions to neurology and ophthalmology across prominent UK institutions. His extensive professional life and achievements are documented through his personal archives.

More Related Videos

Depletion and Reconstitution of Macrophages in Mice

Depletion and Reconstitution of Macrophages in Mice

Published on: August 1, 2012

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Related Experiment Videos

Last Updated: May 31, 2026

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

Published on: July 20, 2011

Depletion and Reconstitution of Macrophages in Mice

Depletion and Reconstitution of Macrophages in Mice

Published on: August 1, 2012

A Mouse Model of Intestinal Partial Obstruction

A Mouse Model of Intestinal Partial Obstruction

Published on: March 5, 2018

Area of Science:

Neurology
Ophthalmology
Medical History

Background:

This biographical account chronicles the life and achievements of William Ian McDonald (1933-2006), a distinguished neurologist and physician.
McDonald held significant positions at the National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital, and the University of London.
He also served as Editor of the journal Brain and Harveian Librarian at the Royal College of Physicians of London.

Discussion:

The abstract draws upon extensive personal archives left by Ian McDonald, providing a detailed look at his professional and private life.
While the archive remains uncatalogued, this account cites material provenance and dates where possible.
The work aims to provide a comprehensive overview of McDonald's contributions to his fields.

Key Insights:

Ian McDonald made significant contributions as a neurologist and physician, bridging neurology and ophthalmology.
His academic and clinical roles at major institutions underscore his impact on medical practice and education.
The meticulous documentation of his life and work offers valuable insights into the history of neurology and ophthalmology.

Outlook:

Further research into McDonald's uncatalogued archives may reveal additional insights into his work and the broader medical landscape of his time.
This biography serves as a foundation for understanding the legacy of a key figure in 20th-century neurology and ophthalmology.
Future studies could explore the impact of his editorial work on the journal Brain and his contributions as Harveian Librarian.