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Role of Jagged1 in arterial lesions after vascular injury

Xiaojing Wu1, Yunzeng Zou, Qi Zhou

  • 1Cardiovascular Center of Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 18, 2011
PubMed
Abstract

Insights

Jagged1, a Notch ligand, inhibits arterial lesion formation by preventing unfavorable changes in vascular smooth muscle cells (VSMC). This suggests Jagged1 as a therapeutic target for aging-related vascular diseases.

Area of Science:

  • Vascular Biology
  • Cellular Signaling
  • Aging Research

Background:

  • Aging is characterized by impaired endothelial cell (EC) regeneration and overactive vascular smooth muscle cells (VSMC), complicating treatment of arterial lesions.
  • Reduced endothelial Jagged1 expression in aged animals correlates with enhanced neointima growth.

Purpose of the Study:

  • To investigate the role of Jagged1 in EC and VSMC function in the context of vascular injury and aging.
  • To explore Jagged1 as a potential therapeutic target for age-related vascular diseases.

Main Methods:

  • Utilized Tie2-cre(+) Jagged1(lox/+) mice with EC-specific Jagged1 knockout to model aging-related vascular changes.
  • Examined Jagged1 expression in EC and VSMC after carotid artery ligation.
  • Performed coculture experiments of VSMC with Jagged1-null EC and overexpression studies.

Main Results:

  • Mice with EC-specific Jagged1 knockout exhibited exaggerated intimal and medial thickening post-injury.
  • Jagged1 expression was unexpectedly low in both EC and VSMC of knockout mice after ligation.
  • Jagged1-null EC induced a synthetic phenotype transition in VSMC, which was prevented by Jagged1 overexpression.

Conclusions:

  • Jagged1 exerts a unidirectional inhibitory effect on arterial lesion development by influencing both EC and VSMC.
  • Jagged1 represents a promising therapeutic target for mitigating aging-related vascular pathologies.

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