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Updated: May 31, 2026
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The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
Published on: February 7, 2025
Acute physiology of stroke score.
1Departments of Neurology, University of Virginia, Charlottesville, VA, USA. kj4v@virginia.edu
Stroke
|June 18, 2011
Summary
The Acute Physiology of Stroke Score (APSS) shows some relation to 3-month outcomes in ischemic stroke patients. However, APSS did not significantly improve predictions when added to existing clinical models.
Area of Science:
- Neurology
- Critical Care Medicine
- Biostatistics
Background:
- The Acute Physiology, Age, Chronic Health Evaluation (APACHE) score is used for predicting outcomes in critically ill patients.
- Developing a similar score for stroke patients could enhance outcome prediction.
Purpose of the Study:
- To develop and validate the Acute Physiology of Stroke Score (APSS).
- To determine if APSS improves outcome prediction when added to a validated clinical model for stroke patients.
Main Methods:
- APSS was developed and validated using multivariable logistic regression.
- APSS was incorporated into a pre-existing clinical prediction model.
- Area under the curve (AUC) was used to assess predictive improvement for 3-month outcomes.
Main Results:
- APSS alone demonstrated an AUC of 0.753 for predicting survival at discharge.
- The established clinical model had AUCs ranging from 0.77 to 0.88.
- Adding APSS to the clinical model resulted in AUCs ranging from 0.77 to 0.89, showing minimal improvement.
Conclusions:
- The APSS is associated with 3-month clinical outcomes in ischemic stroke patients.
- APSS does not provide clinically significant additional predictive value when combined with the validated clinical model.
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