Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Alterations in Respiration II

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Vocal cord dysfunction in athletes: Interest of rehabilitation to effort].

Revue des maladies respiratoires·2021

Same author

Impact of extracorporeal membrane oxygenation (ECMO) support on piperacillin exposure in septic patients: a case-control study.

The Journal of antimicrobial chemotherapy·2021

Same author

When helping the minority of patients may hurt the majority: The case for DPD phenotyping and 5-fluorouracil therapeutic drug monitoring.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2020

Same author

Efficacy of generic meropenem products in combination with colistin in carbapenemase-producing Klebsiella pneumoniae experimental osteomyelitis.

International journal of antimicrobial agents·2020

Same author

Measurement of f_{s}/f_{u} Variation with Proton-Proton Collision Energy and B-Meson Kinematics.

Physical review letters·2020

Same author

Search for A^{'}→μ^{+}μ^{-} Decays.

Physical review letters·2020

Search research articles

Related Experiment Video

Updated: May 31, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Dynamic cardiorespiratory changes in obese women.

I Castres¹, F Lemaitre, C Tardif

¹CETAPS, EA3832, Faculty of Sport Sciences, University of Rouen, Rouen, France.

The Journal of Sports Medicine and Physical Fitness

|June 18, 2011

Summary

This 12-week exercise program improved cardiorespiratory function and body composition in obese women. While not reaching sedentary healthy levels, it enhanced physiological variables and exercise response.

More Related Videos

Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects

Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects

Published on: February 12, 2021

Related Experiment Videos

Last Updated: May 31, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects

Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects

Published on: February 12, 2021

Area of Science:

Exercise Physiology
Obesity Research
Cardiorespiratory Health

Background:

Obesity is linked to impaired cardiorespiratory function and altered body composition.
Exercise interventions are crucial for managing obesity and improving health outcomes.
Understanding the impact of exercise on physiological variables in obese individuals is essential.

Purpose of the Study:

To investigate the effects of a combined strength and aerobic exercise program on ventilatory function and cardiorespiratory response in obese women.
To assess changes in body composition following the exercise intervention.
To evaluate the relationship between exercise training and physiological improvements in an obese cohort.

Main Methods:

Ten obese women (53.4±7.6 years) underwent a 12-week exercise program (3x/week, 90 min) combining strength and aerobic training at ventilatory threshold.
Initial and post-training assessments included exercise testing and anthropometric measurements.
Data analysis focused on changes in ventilatory efficiency (ΔVE/ΔCO2) and cardiac efficiency (ΔHR/ΔO2), alongside body composition metrics.

Main Results:

Significant improvements were observed in ventilatory efficiency (ΔVE/ΔCO2) and cardiac efficiency (ΔHR/ΔO2) (P<0.05).
Body composition changes included decreased fat mass (-1.2 kg) and increased lean body mass (+1 kg) (P<0.01).
Significant reductions in waist (-5.5 cm) and hip (-5 cm) circumferences were also noted (P<0.05).

Conclusions:

The functional exercise program significantly enhanced physiological variables and cardiorespiratory response to exercise in obese women.
Improvements were noted in ventilatory and cardiac efficiency, alongside positive body composition changes.
While beneficial, the program did not fully restore physiological function to levels seen in sedentary healthy individuals.