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Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...

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Related Experiment Video

Updated: May 31, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

Environmental epigenomics and disease susceptibility.

Michael K Skinner1

  • 1Center for Reproductive Biology, School of Biological Sciences, Washington State University, USA. skinner@wsu.edu

EMBO Reports
|June 18, 2011
PubMed
Summary

Environmental epigenetics research defines its role in disease susceptibility. Studies presented at the Keystone symposium highlighted how environmental factors influence gene expression and disease risk.

Area of Science:

  • Environmental Epigenomics
  • Disease Susceptibility
  • Molecular Biology

Background:

  • The field of environmental epigenetics is rapidly developing.
  • Epigenetic modifications are influenced by environmental exposures.
  • Understanding these mechanisms is crucial for disease etiology.

Purpose of the Study:

  • To define the scope and key research areas within environmental epigenetics.
  • To establish the role of environmental epigenetics in disease aetiology and susceptibility.
  • To foster collaboration and knowledge exchange in this emerging scientific domain.

Main Methods:

  • The content is based on presentations and discussions from the Keystone symposium.
  • Research encompassed various methodologies including molecular biology, toxicology, and epidemiology.

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

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Methylated DNA Immunoprecipitation
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Methylated DNA Immunoprecipitation

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Last Updated: May 31, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)

Published on: August 21, 2016

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

  • Data synthesis and expert consensus building were key components.

    • Main Results:

    • Environmental epigenetics is a critical determinant of disease susceptibility.
    • Specific epigenetic mechanisms link environmental exposures to altered gene function.
    • The presented research established a strong connection between epigenetics and various diseases.

    Conclusions:

    • Environmental epigenetics is a vital and evolving field.
    • Further research is needed to fully elucidate the complex interactions between environment, epigenome, and health.
    • This field holds significant promise for understanding and preventing diseases.