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Updated: May 31, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Atopic dermatitis-like pre-Sézary syndrome: role of immunosuppression
Małgorzata Sokołowska-Wojdyło1, Wioletta Barańska-Rybak, Agnieszka Cegielska
1Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Poland. mwojd@gumed.edu.pl
Abstract:
We describe here 4 patients with Sézary syndrome masquerading as adult-onset atopic dermatitis. The patients presented with a clinical picture compatible with wide-spread atopic dermatitis and did not fulfil the criteria for Sézary syndrome (lack of lymphoadenopathy and blood involvement, skin histology without presence of atypical cells). In our patients, overt Sézary syndrome developed after immunosuppressive treatment (including cyclosporine). These cases support the validity of the concept of pre-Sézary syndrome, which is a long-lasting, pre-malignant condition, and which may develop to true malignancy in a state of immunosuppression.
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