Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Active versus Passive Immunity01:31

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Allergic Reactions02:06

Allergic Reactions

Overview
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Cross-reactivity00:42

Cross-reactivity

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Involution of IgE sensitization to house dust mite allergen molecules by age.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Irritant occupational exposure and specific-IgE sensitisation in the EGEA cohort.

Occupational and environmental medicine·2026
Same author

Discovery of tumor antigens in renal cell carcinoma and prospects for clinical application.

Frontiers in immunology·2026
Same author

Birch Pollen Exposure Boosts Mal d 1-Specific IgE and Sensitivity to Apple.

Allergy·2026
Same author

Reply.

The Journal of allergy and clinical immunology·2026
Same author

Algorithms in Allergy: General Allergen Molecule-Based Algorithm for Allergen-Specific Immunotherapy.

Allergy·2026
Same journal

Correction to: Resolution of Skeletal Muscle Inflammation: Role of Specialized Pro-resolving Lipid Mediators in the Recovery from Exercise, Injury, and Disease.

Current topics in microbiology and immunology·2026
Same journal

Resolution Biology in Soft Tissue Joint Disease.

Current topics in microbiology and immunology·2026
Same journal

A 25+ Year Journey on Yeast-Regulated Cell Death Research.

Current topics in microbiology and immunology·2026
Same journal

Adoptive T-Cell Immunotherapy.

Current topics in microbiology and immunology·2026
Same journal

Resolution Pharmacology Targeting the Melanocortin System.

Current topics in microbiology and immunology·2026
Same journal

Resolution of Skeletal Muscle Inflammation: Role of Specialized Pro-resolving Lipid Mediators in the Recovery from Exercise, Injury, and Disease.

Current topics in microbiology and immunology·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Passive immunization with allergen-specific antibodies.

Sabine Flicker1, Elisabeth Gadermaier, Christoph Madritsch

  • 1Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Vienna General Hospital, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. sabine.flicker@meduniwien.ac.at

Current Topics in Microbiology and Immunology
|June 18, 2011
PubMed
Summary
This summary is machine-generated.

Allergen-specific IgG antibodies reduce allergic inflammation. Engineered antibodies offer potential for allergy treatment and prevention through passive immunization.

More Related Videos

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Related Experiment Videos

Last Updated: May 31, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Area of Science:

  • Immunology
  • Allergy Research
  • Biotechnology

Background:

  • Allergen-specific immunotherapy reduces allergic inflammation.
  • Allergen-specific IgG antibodies are key mediators in this reduction.
  • These IgG antibodies inhibit mast cell degranulation and IgE production.

Purpose of the Study:

  • To review the role of allergen-specific antibodies in allergy treatment and prevention.
  • To explore the potential of engineered antibodies for passive immunization.
  • To outline strategies for allergy management using blocking antibodies.

Main Methods:

  • Review of existing studies on allergen-specific IgG antibodies.
  • Discussion of recombinant allergen and antibody production technologies.
  • Envisioning therapeutic and prophylactic approaches.

Main Results:

  • Allergen-specific IgG antibodies effectively block allergic reactions.
  • Recombinant antibody technology enables development of therapeutic agents.
  • Passive immunization with antibodies shows promise for allergy control.

Conclusions:

  • Allergen-specific antibodies are crucial for reducing allergic inflammation.
  • Engineered antibodies represent a viable strategy for allergy therapy and prophylaxis.
  • Future approaches may involve targeted antibody-based interventions for allergy management.