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[Profile of biochemical markers in cystic fibrosis. Prospective study about 13 cases]
Raja Belhaj1, Wided Souissi, Sondes Hadj frej
1Universite Tunis, El Manar, Tunisie.
Insights
Biochemical analysis in cystic fibrosis (CF) patients revealed significant nutritional deficiencies, particularly low zinc levels in all participants. This highlights the importance of monitoring trace elements for assessing CF patient nutritional status.
Area of Science:
- Biochemistry
- Pediatrics
- Nutritional Science
Context:
- Cystic fibrosis (CF) is a genetic disorder affecting multiple organs, often leading to malnutrition.
- Assessing the nutritional state in CF patients is crucial for disease management and prognosis.
- Biochemical markers provide valuable insights into metabolic disturbances in CF.
Purpose:
- To investigate biochemical parameter disturbances related to nutritional status in pediatric cystic fibrosis patients.
- To evaluate the levels of key nutrients including protein, calcium, magnesium, zinc, and iron in suspected CF cases.
- To establish the correlation between biochemical findings and the nutritional state in cystic fibrosis.
Summary:
- A prospective study of 13 pediatric patients (2 months-12 years) with suspected cystic fibrosis was conducted over 7 months.
- Results indicated hypoproteinemia in 6 cases, hypocalcemia in 3, and hypomagnesemia in 2.
- All patients exhibited low zinc levels, and 5 cases showed low iron concentrations, underscoring widespread trace element deficiencies.
Impact:
- The study emphasizes the critical role of monitoring biochemical parameters, especially trace elements, for evaluating the nutritional status of cystic fibrosis patients.
- Findings can inform clinical practice by guiding targeted nutritional interventions and improving patient outcomes.
- This research contributes to a better understanding of the metabolic complications associated with cystic fibrosis.
Background:
To study the disturbances of biochemical parameters which make it possible to evaluate the nutritional state during the cystic fibrosis.
Methods:
Prospective study about 13 cases hospitalized over a 7 months period, whose age varies between 2 months and 12 years and addressed for a suspicion of cystic fibrosis. For all the patients we made a clinical collection of the data and a biochemical study.
Results:
Hypoprotidemia (protidemia < 60 g/l) was noted in 6 cases. Three cases presented a hypocalcaemia (calcemia < 2.20 mmol/l). A hypomagnesaemia (magnesemia < 0.70 mmol/L) was observed in 2 cases. The totality of the patients presented zinc concentrations lower than the normal value. Iron concentrations lower than the normal (11- 24 mmol/l) was noted in 5 cases. Four patients (4/13) presented a concentration of iron between 11.2 and 20 mmol/l, whereas a high concentration (32.3 mmol/l) was noted in only one case (7.7%).
Conclusion:
The study of the biochemical parameters allowed to evaluate the variation of some trace elements in cystic fibrosis and their consequence on the nutritional state of the patients, which constitutes an essential element for the assessment of these patients.
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