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Poly(dimethyl siloxane) surface modification with biosurfactants isolated from probiotic strains.
1Department of Chemical Engineering, University of Coimbra, Polo II, Pinhal de Marrocos, 3030-790 Coimbra, Portugal. susanacspinto@gmail.com.
Journal of Biomedical Materials Research. Part A
|June 18, 2011
Summary
Coating poly(dimethyl siloxane) (PDMS) surfaces with biosurfactants (BSs) enhances hydrophilicity and improves blood compatibility. This surface modification is non-toxic and shows promise for biomedical applications.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Microbiology
Background:
- Biomaterial performance in biological settings is dictated by surface properties.
- Surface modification is crucial for optimizing biomaterials for specific applications.
- Poly(dimethyl siloxane) (PDMS) is a common biomaterial requiring surface functionalization.
Purpose of the Study:
- To coat poly(dimethyl siloxane) (PDMS) surfaces with biosurfactants (BSs).
- To evaluate the impact of BS coating on PDMS surface properties and biological performance.
- To explore potential biomedical applications of modified PDMS.
Main Methods:
- Surface modification of PDMS with biosurfactants from four probiotic strains.
- Characterization using contact angle, ATR-FTIR, XPS, and AFM.
- Assessment of blood compatibility via thrombosis and hemolysis assays.
- Cytotoxicity testing using rat peritoneal macrophages.
Main Results:
- AFM confirmed successful surface coating.
- Contact angle measurements showed increased surface hydrophilicity.
- XPS revealed decreased surface silicon content.
- ATR-FTIR detected characteristic BS functional groups.
- All modified materials exhibited no toxicity and were non-hemolytic.
Conclusions:
- Biosurfactant coating effectively modifies PDMS surface properties, enhancing hydrophilicity.
- The modified PDMS surfaces demonstrate excellent blood compatibility and low toxicity.
- This approach offers new opportunities for PDMS in biomedical applications.
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