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[Bronchioloalveolar carcinoma producing CA19-9].
Takehiro Sakai1, Takao Tsushima, Daisuke Kimura
1Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|June 21, 2011
Summary
A 76-year-old man with a history of laryngeal cancer developed an abnormal lung lesion. Diagnosis confirmed primary lung adenocarcinoma, stage IB, with elevated CA19-9 levels.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- A 76-year-old male patient with a history of laryngeal cancer treated with radiation therapy presented with an abnormal pulmonary finding.
Observation:
- Computed tomography revealed a 4.6 cm lesion in the upper lobe of the left lung.
- Endoscopic brushing cytology diagnosed adenocarcinoma.
- Preoperative serum carbohydrate antigen 19-9 (CA19-9) was elevated at 250 U/ml.
Findings:
- The patient was diagnosed with primary lung cancer, clinical stage IB (T2N0M0).
- Histopathological examination classified the lesion as a well-differentiated adenocarcinoma, mucinous subtype of bronchioloalveolar carcinoma (BAC) according to the World Health Organization (WHO) classification.
- Immunohistochemistry confirmed positivity for CA19-9 and thyroid transcription factor-1 (TTF-1).
Implications:
- This case highlights the importance of investigating new pulmonary lesions in patients with a history of other cancers.
- Elevated CA19-9 may serve as a potential biomarker in select cases of lung adenocarcinoma.
- The findings contribute to understanding the pathological spectrum and diagnostic markers of lung adenocarcinoma, particularly bronchioloalveolar carcinoma.