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Updated: May 31, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Bioactive neo-clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge
1College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
Abstract:
Ten new neo-clerodane diterpenes, ajugaciliatins A-J (1-5, 8-12), along with 17 known analogues (6, 7, 13-27) were isolated from the whole plants of Ajuga ciliata Bunge. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the configuration of 1 was confirmed by X-ray crystallography. All of the compounds were assessed for neuroprotective effects against MPP(+)-induced neuronal cell death in dopaminergic neuroblastoma SH-SY5Y cells. Compounds 2, 6, 7, 9, 10, 15-17, 19, and 20 exhibited moderate neuroprotective effects.
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