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Related Experiment Video

Updated: May 31, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Organizing DNA origami tiles into larger structures using preformed scaffold frames.

Zhao Zhao¹, Yan Liu, Hao Yan

¹Department of Chemistry and Biochemistry and The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States.

|June 21, 2011

Summary

Researchers developed "superorigami," a novel DNA nanotechnology method. This technique enables the creation of larger, spatially organized DNA nanostructures by assembling smaller DNA origami tiles.

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Area of Science:

Nanotechnology
Structural DNA Nanotechnology
Molecular Engineering

Background:

Structural DNA nanotechnology uses DNA as programmable polymers for nanoscale construction.
Scaffolded DNA origami, a key advancement, folds long DNA scaffolds with short staple strands into desired shapes.
Current DNA origami dimensions are limited by scaffold strand length.

Purpose of the Study:

To overcome the dimensional limitations of existing DNA origami technology.
To introduce a scalable method for creating larger DNA nanostructures.
To demonstrate a new strategy for organizing DNA origami tiles into complex architectures.

Main Methods:

Development of a "superorigami" or "origami of origami" strategy.
Utilizing bridge strands to prefold a single-stranded DNA scaffold into a framework.
Directing preformed DNA origami tiles onto the scaffold framework, where tiles act as large staples.

Main Results:

Demonstration of a scalable DNA origami technique.
Successful organization of DNA origami nanostructures into larger, spatially addressable architectures.
Validation of the "superorigami" approach for constructing complex nanoscale assemblies.

Conclusions:

The superorigami strategy effectively scales up DNA origami technology.
This method allows for the creation of significantly larger and more complex DNA-based nanostructures.
The approach holds promise for advanced applications in molecular assembly and nanotechnology.