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Papillomavirus common antigen in Bowen's disease
E I Grussendorf-Conen1, M Giesen
1Department of Dermatology, Medical Faculty, Rhenish-Westphalian Technical University, Aachen, FRG.
Dermatologica
|January 1, 1990
Summary
Human papillomaviruses (HPVs) were detected in 22.5% of Bowen's disease biopsies. Genital skin lesions showed a higher prevalence of HPV antigen, suggesting a role in skin cancer development.
Area of Science:
- Dermatology
- Virology
- Oncology
Background:
- Bowen's disease is a form of squamous cell carcinoma in situ.
- The role of viral infections in skin cancer development is an area of ongoing research.
- Human papillomaviruses (HPVs) are known oncogenic viruses.
Purpose of the Study:
- To investigate the presence of human papillomavirus (HPV) antigen in Bowen's disease biopsies.
- To determine if HPV prevalence differs based on lesion location.
- To explore the potential etiologic role of HPV in Bowen's disease.
Main Methods:
- Study included 173 biopsies of histologically confirmed Bowen's disease.
- Immunoperoxidase staining was used to detect papillomavirus capsid antigen.
- Lesion locations were categorized as head, extremities, trunk, or genital region.
Main Results:
- HPV capsid antigen was identified in 39 (22.5%) of the 173 biopsies.
- A higher prevalence of HPV antigen was found in genital lesions (38%) compared to other skin regions (19.4%).
- The overall detection rate suggests a significant association between HPV and Bowen's disease.
Conclusions:
- Findings suggest an etiologic relationship between HPV and Bowen's disease.
- HPV may play a significant role in the development of cutaneous malignancies.
- Further research is warranted to elucidate the precise mechanisms of HPV involvement in skin carcinogenesis.