Related Experiment Video
Updated: May 31, 2026

Models of Bone Metastasis
Published on: September 4, 2012
Mechanisms of cancer-induced bone pain
T Middlemiss1, B J A Laird, M T Fallon
1University of Edinburgh, Edinburgh, UK. tommiddlemiss@hotmail.com
Abstract:
Cancer-induced bone pain (CIBP) is common and challenging to treat. Common therapies, such as opioids, radiotherapy and bisphosphonates, are often only partially effective. CIBP is a different entity to inflammatory or neuropathic pain and needs to be considered as such. This overview examines the mechanisms of CIBP; the imbalance of bone turnover, peripheral and central nervous involvement and key neurochemical mediators. The current understanding of the underlying pathophysiology of CIBP is discussed.
Related Concept Videos
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Nociception
Analgesia and Pain Management
Bone Remodeling
Osteoclasts in Bone Remodeling
