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Avian oncovirus Mill Hill No. 2: pathogenicity in chickens
Journal of the National Cancer Institute
|February 1, 1979
Summary
Mill Hill No. 2 (MH2) avian tumor virus causes liver and kidney carcinoma, and sarcoma in chickens. Associated viruses induce lymphoma, highlighting MH2
Area of Science:
- Oncology
- Virology
- Pathology
Background:
- Mill Hill No. 2 (MH2) is an avian tumor virus with known transforming capabilities.
- Understanding the oncogenic potential of MH2 is crucial for avian cancer research.
Purpose of the Study:
- To investigate the transforming and oncogenic effects of Mill Hill No. 2 (MH2) avian tumor virus.
- To characterize the histologic features of tumors induced by MH2 and associated viruses.
Main Methods:
- Tissue culture experiments to assess cellular transformation.
- In vivo injection into chickens to evaluate oncogenic effects.
- Light and electron microscopy for detailed tumor histology.
Main Results:
- MH2 virus induced transformation of chicken fibroblasts and yolk sac macrophages in vitro.
- In vivo, MH2 caused liver and kidney carcinomas, and sarcoma at injection sites.
- MH2-associated viruses induced lymphoma but did not transform cell cultures.
- Histologic analysis revealed unclassified round cell sarcoma, mixed kidney carcinomas, and dominant hepatocarcinomas.
- Lymphomas induced by associated viruses were poorly differentiated and highly malignant.
Conclusions:
- MH2 virus exhibits significant oncogenic potential in chickens, causing diverse tumor types.
- The study provides a model for analyzing specific carcinogenic events.
- MH2-associated viruses have distinct oncogenic properties, primarily causing lymphoma.