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Related Experiment Video

Updated: May 31, 2026

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity
09:09

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity

Published on: May 28, 2014

Breathing patterns after mid-cervical spinal contusion in rats.

F J Golder1, D D Fuller, M R Lovett-Barr

  • 1Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706-1102, USA.

Experimental Neurology
|June 21, 2011
PubMed
Summary

Cervical spinal cord injury alters breathing patterns, with injury severity correlating to reduced tidal volume and increased respiratory rate. These changes in breathing reflect neural plasticity following the injury.

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Area of Science:

  • Neuroscience
  • Respiratory Physiology
  • Spinal Cord Injury Research

Background:

  • Respiratory failure is a primary cause of mortality following cervical spinal cord injury.
  • Incomplete cervical spinal injuries are known to disrupt respiratory patterns and induce neural plasticity.
  • The relationship between injury severity and breathing pattern changes requires further elucidation.

Purpose of the Study:

  • To investigate how incomplete cervical spinal cord injuries alter respiratory patterns.
  • To determine if injury severity correlates with changes in breathing patterns.
  • To explore the role of central nervous system plasticity in post-injury respiratory dysfunction.

Main Methods:

  • C4-C5 spinal cord contusions were induced in Sprague Dawley rats.

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Published on: June 14, 2024

A Contusion Model of Severe Spinal Cord Injury in Rats
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A Contusion Model of Severe Spinal Cord Injury in Rats

Published on: August 17, 2013

Related Experiment Videos

Last Updated: May 31, 2026

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity
09:09

A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity

Published on: May 28, 2014

Assessing Functional Recovery of Eupneic Diaphragm Activity Following Unilateral Cervical Spinal Cord Hemisection in Rats
05:09

Assessing Functional Recovery of Eupneic Diaphragm Activity Following Unilateral Cervical Spinal Cord Hemisection in Rats

Published on: June 14, 2024

A Contusion Model of Severe Spinal Cord Injury in Rats
10:00

A Contusion Model of Severe Spinal Cord Injury in Rats

Published on: August 17, 2013

  • Respiratory frequency and tidal volume were measured in unanesthetized rats using whole-body plethysmography.
  • Phrenic motor output was recorded in anesthetized, vagotomized, and ventilated rats to assess neural control.
  • Histological analysis quantified the extent of spinal cord injury via cyst area measurements.

    • Main Results:

    • In unanesthetized rats, increased injury severity correlated with decreased tidal volume (R(2)=0.85) and increased breathing frequency (R(2)=0.65).
    • In anesthetized rats, phrenic burst amplitude decreased ipsilaterally, and burst frequency negatively correlated with contusion size (R(2)=0.51).
    • A strong correlation was observed between breathing patterns in unanesthetized and anesthetized states, suggesting intrinsic neural mechanisms.

    Conclusions:

    • The severity of C4-C5 spinal contusion directly influences post-injury breathing patterns.
    • Altered respiratory motor output following spinal cord injury is partly mediated by intrinsic neural plasticity.
    • These findings highlight the neural mechanisms underlying respiratory dysfunction after cervical spinal cord injury.