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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Published on: July 19, 2019

Vascular aspects of multiple sclerosis.

Miguel D'haeseleer1, Melissa Cambron, Ludo Vanopdenbosch

  • 1Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. miguel.dhaeseleer@uzbrussel.be

The Lancet. Neurology
|June 21, 2011
PubMed
Summary

Multiple sclerosis (MS) patients exhibit increased risk for ischemic stroke due to vascular dysfunctions like endothelial dysfunction and cerebral hypoperfusion. These issues may also contribute to MS pathology and cognitive decline.

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Area of Science:

  • Neuroscience
  • Vascular Biology
  • Neurology

Background:

  • Multiple sclerosis (MS) is associated with three distinct vascular dysfunctions.
  • Epidemiological data indicate a higher risk of ischemic stroke in MS patients.
  • Potential mechanisms include endothelial dysfunction and elevated homocysteine levels.

Purpose of the Study:

  • To explore the multifaceted vascular dysfunctions observed in multiple sclerosis.
  • To investigate the link between cerebral hypoperfusion and MS pathology.
  • To examine the role of venous drainage abnormalities in MS.

Main Methods:

  • Review of epidemiological studies on stroke risk in MS.
  • Analysis of cerebral perfusion data in MS patients.
  • Evaluation of theories regarding chronic cerebrospinal venous insufficiency (CCSVI).

Main Results:

  • MS patients show increased ischemic stroke risk, possibly due to endothelial dysfunction.
  • Global cerebral hypoperfusion is observed in MS, potentially linked to reduced axonal activity and altered metabolism.
  • Some aspects of CCSVI may be explained by slower venous blood flow secondary to reduced cerebral perfusion.

Conclusions:

  • Vascular dysfunction is a significant factor in multiple sclerosis.
  • Cerebral hypoperfusion and potential venous drainage issues warrant further investigation in MS.
  • Understanding these vascular aspects may offer new therapeutic targets for MS.