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Updated: May 31, 2026
09:54
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
[Anaesthesia for HIV-infected patients]
1Pôle d'anesthésie réanimation chirurgicale, hôpital Archet 2, CHU de Nice, université de Nice-Sophia-Antipolis, 151 route de Saint-Antoine-Ginestière, Nice cedex, France.
Annales Francaises D'Anesthesie Et De Reanimation
|June 21, 2011
Summary
Managing HIV patients requires careful perioperative planning. Optimal care involves minimizing treatment breaks, monitoring for complications like cognitive dysfunction and metabolic issues, and ensuring continuity of combined antiretroviral therapy (cART).
Area of Science:
- Anesthesiology
- Infectious Diseases
- Pharmacology
Context:
- France faces a significant HIV epidemic, with over 120,000 cases and 34,600 AIDS diagnoses.
- Combined antiretroviral therapy (cART) has halved HIV-related mortality but requires strict adherence.
- Low cART compliance compromises virologic control and increases morbidity and mortality.
Purpose:
- To outline essential perioperative considerations for human immunodeficiency virus (HIV)-infected patients.
- To highlight potential complications and drug interactions relevant to anesthesia and surgical care.
- To emphasize the importance of multidisciplinary collaboration for optimal patient outcomes.
Summary:
- Perioperative care for HIV patients necessitates addressing respiratory, neurological, metabolic (lipodystrophy, dyslipidemia, insulin resistance), and nutritional issues.
- Regional anesthesia is generally safe; however, caution is advised with protease inhibitors due to potential interactions with opioids, NSAIDs, and benzodiazepines.
- Postoperative management includes vigilance for thromboembolism, cardiovascular events, nutritional status, and uninterrupted cART, alongside psychological support.
Impact:
- Informed perioperative strategies can mitigate risks associated with HIV and cART, improving surgical outcomes.
- Awareness of drug-drug interactions, particularly with protease inhibitors, is crucial for anesthetic drug selection.
- Comprehensive patient management, including psychological support and physician collaboration, is vital for successful HIV care.
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